| CAS NO: | 185991-24-6 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 生物活性 | AMD 3465 (GENZ-644494) is a potent antagonist ofCXCR4, inhibits binding of 12G5 mAb and CXCL12AF647toCXCR4, withIC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication ofX4HIVstrains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses. | |||||||||
| IC50& Target[1] |
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| 体外研究 (In Vitro) | AMD 3465 is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells. AMD 3465 (50 nM) totally blocks CXCL12-induced calcium mobilization, with an IC50of 17 nM, but shows no effect on the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78β and MIP-1β in U87.CD4.CCR5 cells. AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses. AMD3465 is cytotoxic to the X4 HIV-1 strains IIIB, NL4.3, RF and HE with an IC50ranging from 6 to 12 nM. The IC50for suppression of the HIV-2 strains ROD and EHO is 12.3 nM[1]. AMD 3465 inhibits CXCL-12-induced growth in U87 and Daoy cells. AMD 3465 treatment stimulates the phosphorylation of Erk1/2 in U87 and Daoy cells[2]. | |||||||||
| 体内研究 (In Vivo) | AMD 3465 (2.5 mg/kg/d, s.c. for 5 weeks) significantly blocks the growth of U87 GBM and Daoy xenografts[2]. | |||||||||
| 分子量 | 410.60 | |||||||||
| Formula | C24H38N6 | |||||||||
| CAS 号 | 185991-24-6 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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