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BACE1-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BACE1-IN-1图片
CAS NO:1310347-50-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
BACE1-IN-1是一种有效且具高度脑渗透性的BACE1抑制剂,对人BACE1和BACE2的IC50值分别为32和47nM。
Cas No.1310347-50-2
Canonical SMILESO=C(C1=NC=C(C#N)C=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)OCC3(F)F)=C2
分子式C18H14F3N5O2
分子量389.33
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.

[1]. Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95.