IRL 2500

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IRL 2500

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

169545-27-1

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议

产品介绍

IRL 2500 是一种有效的内皮素受体 (Endothelin receptor) 拮抗剂，其 ET_B和 ET_A受体的IC₅₀值分别为 1.3 和 94 nM。 IRL 2500 在体内抑制 ETB 受体介导的血压升高和肾血管阻力。

生物活性

IRL 2500 is a potentEndothelin receptorantagonist. IRL 2500 showsIC₅₀ values of 1.3 and 94 nM for ET_B and ET_A receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo^[1].

IC₅₀& Target^[1]

ET_B

1.3 nM (IC₅₀)

ET_A

94 nM (IC₅₀)

体内研究
(In Vivo)

IRL 2500 (intravenous injection;10 mg/kg) inhibits the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 in rats, IRL 2500 also attenuates the IRL 1620-mediated increase in renal vascular resistance (RVR) in the anesthetized rat^[1].
IRL 2500 (intravenous injection;10 mg/kg) pre-reatment significantly reduces the initial vasodepressor response to endothelin-1 (ET-1) and IRL 1620, however, it is not alters the secondary and sustained pressor response to these agonists^[2].

分子量

573.68

性状

Solid

Formula

C₃₆H₃₅N₃O₄

CAS 号

169545-27-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(174.31 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.7431 mL	8.7157 mL	17.4313 mL
5 mM	0.3486 mL	1.7431 mL	3.4863 mL
10 mM	0.1743 mL	0.8716 mL	1.7431 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。