Bosentan-d4 is the deuterium labeled Bosentan. Bosentan is a competitive and dual antagonist ofendothelin-1 (ET)for theET_AandET_Breceptors withK_iof 4.7 nM and 95 nM in human SMC, respectively.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

555.64

C₂₇H₂₅D₄N₅O₆S

1065472-77-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.