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Metyrosine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Metyrosine图片
CAS NO:672-87-7
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
Metyrosine 是一种选择性酪氨酸羟化酶 (tyrosine hydroxylase enzyme) 抑制剂。Metyrosine 具有抗炎和抗溃疡作用。Metyrosine 显著抑制高 COX-2 活性。Metyrosine 是一种非常有效的控制血压的药物。
生物活性

Metyrosine is a selectivetyrosine hydroxylase enzymeinhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits highCOX-2activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

体外研究
(In Vitro)

Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2].

体内研究
(In Vivo)

Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1].
Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1].

Animal Model:Male albino Wistar rats (carrageenan-induced rat paw edema)[2]
Dosage:50, 100 or 200 mg/kg
Administration:I.p.
Result:Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).
Clinical Trial
分子量

195.22

性状

Solid

Formula

C10H13NO3

CAS 号

672-87-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : 5 mg/mL(25.61 mM;ultrasonic and warming and adjust pH to 2 with HCl and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM5.1224 mL25.6121 mL51.2243 mL
5 mM1.0245 mL5.1224 mL10.2449 mL
10 mM0.5122 mL2.5612 mL5.1224 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。