Diclofenac-d4 is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as aCOXinhibitor, withIC₅₀s of 4 and 1.3 nM for humanCOX-1andCOX-2in CHO cells^[1], and 5.1 and 0.84 μM for ovineCOX-1andCOX-2, respectively^[2]. Diclofenac inducesapoptosisof neural stem cells (NSCs) via the activation of thecaspasecascade^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

300.17

C₁₄H₇D₄Cl₂NO₂

153466-65-0

双氯芬酸 D4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.