CAS NO: | 52705-93-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Ginsenoside Rd inhibits TNFα-inducedNF-κBtranscriptional activity with anIC50of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression ofCOX-2andiNOSmRNA. Ginsenoside Rd also inhibitsCa2+influx. Ginsenoside Rd inhibitsCYP2D6,CYP1A2,CYP3A4, andCYP2C9, withIC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively. | ||||||||||||||||
IC50& Target[1][2][4]
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体外研究 (In Vitro) | Ginsenoside Rd is one of the most abundant ingredients ofPanax ginseng. Ginsenoside Rd significantly inhibits TNF-α-induced NF-κB transcriptional activity with an IC50of 12.05±0.82 in HepG2 cells. Ginsenoside Rd also inhibits expression of COX-2 and iNOS mRNA and iNOS promoter activity in a dose-dependent manner. To determine nontoxic concentrations, HepG2 cells are treated with various concentrations (0.1, 1, and 10 μM) of compounds (e.g., Ginsenoside Rd) and cell viability is measured using an MTS assay. No compounds are significantly cytotoxic at up to 10 μM, indicating that NF-κB inhibition is not due to cell toxicity[1]. Ginsenoside Rd is one of the most abundant ingredients ofPanax ginseng, protects the heart via multiple mechanisms including the inhibition of Ca2+influx. Ginsenoside Rd reducesICa,Lpeak amplitude in a concentration-dependent manner (IC50=32.4±7.1 μM)[2]. Ginsenoside Rd exhibits an inhibition against the activity of CYP2D6 in human liver microsomes with an IC50of 58.0±4.5 μM, a weak inhibition against the activity of CYP1A2, CYP3A4, and CYP2C9 in human liver microsomes with IC50s of 78.4±5.3, 81.7±2.6, and 85.1±9.1, respectively, and an even weaker inhibition against the activity of CYP2A6 in human liver microsomes with an IC50value of more than 100 μM[4]. | ||||||||||||||||
体内研究 (In Vivo) | Ginsenosides Rd is a major compound isolated fromGynostemma pentaphyllumthat holistically improves gut microenvironment and induces anti-polyposis in ApcMin/+mice. Six-weeks-old mice are subjected to Ginsenoside Rd treatment, before the appearance of the intestinal polyps. All the mice are monitored for food intake, water consumption, and weight changes. Throughout the experiment, no Rb3/ Ginsenoside Rd-associated weight loss in mice is observed. In addition, none of the treated mice show variations in food and water consumption. Whereas, the number and size of the polyps are effectively reduced by Ginsenoside Rd treatments[3]. | ||||||||||||||||
分子量 | 947.15 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C48H82O18 | ||||||||||||||||
CAS 号 | 52705-93-8 | ||||||||||||||||
中文名称 | 人参皂苷 Rd | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(105.58 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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