Nitroaspirin

立即咨询

Nitroaspirin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	175033-36-0
包装:	5mg
市场价:	4900元

产品名称

NCX 4016

产品介绍

Nitroaspirin (NCX 4016) 是一氧化氮 (NO) 供体和阿司匹林的硝基衍生物，Aspirin 与 Nitroaspirin 联合以抑制环加氧酶。Nitroaspirin (NCX 4016) 具有抗血栓形成和抗血小板特性，并作为COX-1的直接和不可逆抑制剂。Nitroaspirin (NCX 4016) 通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白，在顺铂耐药人卵巢癌细胞中引起细胞周期停滞和凋亡。

生物活性

Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor ofCOX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest andapoptosisin Cisplatin-resistant human ovariancancercells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation ofBcl-2 familyproteins^[1]^[2]^[3]^[4].

IC₅₀& Target^[3]

COX-1

Clinical Trial

分子量

331.28

Formula

C₁₆H₁₃NO₇

CAS 号

175033-36-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.