| CAS NO: | 30636-90-9 |
| 包装: | 20mg |
| 市场价: | 1050元 |
| Cas No. | 30636-90-9 |
| 别名 | 20 (S)-原人参二醇; 20-Epiprotopanaxadiol; 20(S)-APPD |
| 化学名 | (3R,5S,8S,9S,10R,12S,14R,17R)-17-((R)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol |
| Canonical SMILES | C/C(C)=C\CC[C@](O)(C)[C@H](CC[C@@]1(C)[C@]2(CC[C@H]34)C)C1[C@@H](O)C[C@H]2[C@@]4(C)CC[C@@H](O)C3(C)C |
| 分子式 | C30H52O3 |
| 分子量 | 460.73 |
| 溶解度 | ≥ 46mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin; apoptosis inducer.IC50 value:Target: apoptosis inducer(20S)-Protopanaxadiol was used to induce cytotoxicity for two human glioma cell lines, SF188 and U87MG. For the SF188 cells, (20S)-Protopanaxadiol activated caspases-3, -8, -7, and -9 within 3 h and induced rapid apoptosis, which could be partially inhibited by a general caspase blocker and completely abolished when the caspase blocker was used in combination with an antioxidant. (20S)-Protopanaxadiol also induced cell death in U87MG cells but did not activate any caspases in these cells [1]. aPPD was able to inhibit P-gp activity as potently as verapamil on MDR cells. The blockage of P-gp activity was highly reversible as wash-out of aPPD resulted in an immediate recovery of P-gp activity. Unlike verapamil, aPPD did not affect ATPase activity of P-gp suggesting a different mechanism of action [2]. References: |
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