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N,N'-bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N,N'-bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine图片
CAS NO:30414-15-4
包装与价格：
包装价格(元)
100 μg电议
500 μg电议

产品介绍
A microbial metabolite with anticancer activity
Cas No.30414-15-4
Canonical SMILESO=C(C1=C(C(O)=CC=C1)O)N[C@H](C(O)=O)COC([C@H](CO)NC(C2=C(C(O)=CC=C2)O)=O)=O
分子式C20H20N2O11
分子量464.4
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N,N'-bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine is a microbial metabolite and degradation product of the bacterial siderophore enterobactin that has been found inStreptomycesand has anticancer activity.1,2,3It inhibits invasion of 26-L5 murine colon cancer cells in a Matrigel™ assay with an IC50value of 2.7 µM.1

1.Igarashi, Y., Iida, T., Fukuda, T., et al.Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces spJ. Antibiot. (Tokyo)65(4)207-209(2012) 2.O'Brien, I.G., Cox, G.B., and Gibson, F.Enterochelin hydrolysis and iron metabolism in Escherichia coliBiochim. Biophys. Acta237(3)537-549(1971) 3.Raines, D.J., Moroz, O.V., Blagova, E.V., et al.Bacteria in an intense competition for iron: Key component of the Campylobacter jejuni iron uptake system scavenges enterobactin hydrolysis productProc. Nat. Acad. Sci. USA113(21)5850-5855(2016)