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COX-2/5-LOX-IN-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
COX-2/5-LOX-IN-3图片
CAS NO:2481484-51-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
COX-2/5-LOX-IN-3 (compound 5b) 是一种COX-2/5-LOX 的有效双重抑制剂,COX-1、COX-2 和 5-LOX 的IC50值分别为 45.73、5.45 和 4.33 μM。COX-2/5-LOX-IN-3 在炎症疾病研究中具有潜在价值。
生物活性

COX-2/5-LOX-IN-3 (compound 5b) is a potent and dualCOX-2/5-LOXinhibitor withIC50values of 45.73, 5.45 and 4.33 μM forCOX-1,COX-2, and5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases[1].

IC50& Target[1]

COX-2

5.45 μM (IC50)

COX-1

45.73 μM (IC50)

5-LOX

4.33 μM (IC50)

体内研究
(In Vivo)

COX-2/5-LOX-IN-3 (compound 5b) (p.o.; male Sprague Dawley rats) shows anti-inflammatory activities in vivo[1].

Animal Model:Male Sprague Dawley rats[1]
Dosage:2.622 X 10-5mol/kg
Administration:Oral administration
Result:The percentage inhibition of edema (%I) reached 58.77% after 4h.
分子量

361.85

Formula

C17H16ClN3O2S

CAS 号

2481484-51-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.