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COX-2-IN-29
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
COX-2-IN-29图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
COX-2-IN-29 (Compound 15b) 是一种选择性的、具有口服活性的COX-2抑制剂,IC50为 0.005 μM。
生物活性

COX-2-IN-29 (Compound 15b) is a selective and orally activeCOX-2inhibitor with anIC50of 0.005 μM[1].

IC50& Target

COX-2

0.005 μM (IC50)

COX-1

> 10 μM (IC50)

体外研究
(In Vitro)

COX-2-IN-29 (Compound 15b) shows metabolic stability with intrinsic clearance value of 39.9 and 40.3 μL/min/mg protein in mouse and human liver microsomes, respectively[1].

体内研究
(In Vivo)

COX-2-IN-29 (Compound 15b) (10 and 20 mg/kg; p.o.; once) shows antinociceptive activity at 20 mg/kg, and shows anti-inflammatory and anti-edema activities[1].

Animal Model:Male CD1 albino mice (23 – 25 g) or male Sprague–Dawley rats weighing approximately 200 – 250 g[1]
Dosage:10 and 20 mg/kg
Administration:PO, once
Result:Induced a reduction of the number of writhes in a statistically significant manner at the minimum dose of 20 mg/kg, while didn’t show any antinociceptive efficacy at 10 mg/kg. Showed a good activity against carrageenan-induced hyperalgesia 30 min after administration, disappearing completely at 1 h after treatment. A very good activity was demonstrated against carrageenan induced edema in the rat paw.
分子量

494.56

Formula

C22H23FN2O6S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.