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Hydrangenol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hydrangenol图片
CAS NO:480-47-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Hydrangenol 是一种口服有效的抗光老化化合物。可从绣球花 (Hydrangea serrata) 的叶中分离。Hydrangenol 通过降低MMP和炎症细胞因子的表达,增加保湿因子和抗氧化基因的水平来预防皱纹的形成。
生物活性

Hydrangenol is an orally active antiphotoaging compound. It can be isolated fromHydrangea serrataleaves. Hydrangenol prevents wrinkle formation by reducingMMPand inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level[1].

IC50& Target[1]

MMP-1

 

MMP-3

 

COX-2

 

IL-6

 

体内研究
(In Vivo)

Hydrangenol (5, 10, 20, 或 40 mg/kg; 口服; 每日给药,共 7 周) 减轻 uvb 照射 HR-1 无毛小鼠的皱纹形成、背厚、脱水和胶原蛋白降解[1]

Animal Model:UVB-irradiated HR-1 hairless mice[1]
Dosage:5, 10, 20, or 40 mg/kg
Administration:Oral gavage; daily for 7 weeks
Result:Increased the expression of involucrin, filaggrin, and aquaporin-3 (AQP3) as well as hyaluronic acid (HA) production via hyaluronidase (HYAL)-1/-2 downregulation.
Increased the expression of Pro-COL1A1.
Decreased the expression matrix metalloproteinase (MMP)-1/-3, cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6).
Attenuated the phosphorylation of mitogen-activated protein kinases (MAPKs) including ERK and p38, activator protein 1 (AP-1) subunit, and signal transduction and activation of transcription 1 (STAT1).
Upregulated the expression of nuclear factor-E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO-1), glutamate cysteine ligase modifier subunit (GCLM), and glutamate cysteine ligase catalysis subunit (GCLC).
分子量

256.25

Formula

C15H12O4

CAS 号

480-47-7

结构分类
  • Phenylpropanoids
  • Coumarins
来源
  • Plants
  • Hydrangeaceae
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.