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LY 178002
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY 178002图片
CAS NO:107889-32-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LY 178002 是一种有效的5-lipoxygenase (5-LPO)phospholipase A2抑制剂,对 5-lipoxygenase 的IC50值为 0.6 μM,能够抑制人多形核白细胞产生 LTB4,同时可相对较弱地抑制cyclooxygenase的活性。
生物活性

LY 178002 is a potent inhibitor of5-lipoxygenase (5-LPO),phospholipaseA2, withIC50of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition oncyclooxygenase.

IC50& Target

PLA2

6.3 μM (IC50)

Cyclooxygenase

 

5-LPO

0.6 μM (IC50)

FCO

4.2 μM (IC50)

体外研究
(In Vitro)

LY178002 inhibits the generation of LTB4, PLA2 and FCO with IC50s of 0.1, 6.3 and 4.2 μM[1].

体内研究
(In Vivo)

LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%[1].

分子量

319.46

Formula

C18H25NO2S

CAS 号

107889-32-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.