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Flosulide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flosulide图片
CAS NO:80937-31-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
ZK 38997
CGP 28238
产品介绍
Flosulide 是一种有效的,选择性的COX-2抑制剂,常用于炎症研究。
生物活性

Flosulide is a potent and selectiveCOX-2inhibitor, used for the treatment for inflammatory diseases.

IC50& Target

COX-2

 

体外研究
(In Vitro)

Flosulide (1 nM-100 μM) causes a concentration-dependent and finally complete inhibition of PGE2 production in the OSC-2 cell line, but with no effect on PG formation in the OSC-1 cells. Flosulide completely suppresses mitotic activity of OSC-2 cells, whereas mitotic activity of OSC-1 cells remain unchanged[2].

体内研究
(In Vivo)

In normovolemic rats, flosulide increases renal plasma flow (RPF) and and glomerular filtration rate (GFR). In hypovolemic rats, flosulide (5-25 mg/kg) reduces RPF and GFR. Flosulide at 5 mg/kg reduces 6-keto-PGF1alpha whereas at 25 mg/kg and after indomethacin at 10 mg/kg a fall in 6-keto-PGF1alpha and TXB2 appeares[1]. Flosulide (0.75 mg/day) significantly reduces proteinuria as compared to aspirin treatment. Plasma protein and albumin levels are significantly lower in the aspirin-treated group than in flosulide-treated rats[3].

分子量

353.34

Formula

C16H13F2NO4S

CAS 号

80937-31-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.