COX-2-IN-2 is a selective and inducibleCOX2inhibitor with anIC₅₀of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.

COX-2-IN-2 shows no COX-1 inhibition even at 100μM^[1].

COX-2-IN-2 has oral ED₅₀values of 0.030 and 0.47mg/kg on adjuvant-induced arthritis and collagen-induced arthritis, respectively, and an ED₃₀value of 7.4mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay. COX-2-IN-2 shows good analgesic activity and no ulcerogenicity^[1].

341.36

C₁₇H₁₂FN₃O₂S

134729-13-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.