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Glucocorticoid receptor-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glucocorticoid receptor-IN-2图片
CAS NO:2664932-65-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Glucocorticoid receptor-IN-2 (Compound WX019) 是一种选择性的糖皮质激素受体 (glucocorticoid receptor (GR)) 调节剂,具有抗炎效果。Glucocorticoid receptor-IN-2 表现出良好的转录抑制活性,对hMMP1IC50值为 0.171 nM,也表现出一定的转录激活活性,对MMTVEC50为 0.94 nM。
生物活性

Glucocorticoid receptor-IN-2 (Compound WX019) is a selectiveglucocorticoid receptor(GR)modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with anIC50of 0.171 nM againsthMMP1, and comparable transcriptional activation activity with anEC50of 0.94 nM againstMMTV[1].

体外研究
(In Vitro)

Glucocorticoid receptor-IN-2 (Compound WX019) inhibits human peripheral blood mononuclear cells TNF-α with an IC50of 0.98 nM[1].
Glucocorticoid receptor-IN-2 shows inhibitory effect on CYP3A4 with an IC50of 9.12 μM[1].

分子量

512.46

Formula

C25H20F4N6O2

CAS 号

2664932-65-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.