CAS NO: | 869974-19-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | INCB13739 is an orally active, potent, selective and tissue-specific11β-HSD1(11β-hydroxysteroid dehydrogenase 1) inhibitor, withIC50values of 3.2 nM (11β-HSD1 enzymatic) and 1.1 nM (11β-HSD1 PBMC), respectively. INCB13739 can be used for type 2 diabetes mellitus (T2DM) and obesity research[1]. | |||||||||||||||||||||||||||||
IC50& Target | IC50: 3.2 nM (11β-HSD1 enzymatic), 1.1 nM (11β-HSD1 PBMC)[1] | |||||||||||||||||||||||||||||
体外研究 (In Vitro) | INCB13739 is >1000-fold selective towards 11β-HSD2, mineralocorticoid receptor (MR), and glucocorticoid receptor (GR)[1]. | |||||||||||||||||||||||||||||
体内研究 (In Vivo) | INCB13739 (Orally) is effectively distributed in the adipose tissue and is inhibiting 11β-HSD1 activity >90% for at least 24 h post-dose[1].
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Clinical Trial | ||||||||||||||||||||||||||||||
分子量 | 467.52 | |||||||||||||||||||||||||||||
Formula | C28H25N3O4 | |||||||||||||||||||||||||||||
CAS 号 | 869974-19-6 | |||||||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |