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AL 082D06
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AL 082D06图片
CAS NO:256925-03-8
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品名称
D06
D-06
产品介绍
AL 082D06 是一种选择性的非甾体类糖皮质激素受体 (GR) 拮抗剂,Ki为 210 nM。
生物活性

AL 082D06 is a selective, nonsteroidalglucocorticoid receptor(GR) antagonist withKiof 210 nM.

IC50& Target

Ki: 210 nM (GR)[1]

体外研究
(In Vitro)

AL 082D06 (D06) binds specifically to GR with nanomolar affinity. Addition of AL 082D06 causes a dose-dependent decrease in transcriptional activation from the MMTV:Luc reporter stimulated with half-maximal DEX concentrations. AL 082D06 acts to antagonize reporter activity using several glucocorticoid-responsive promoter- reporter systems including the 3-kb tyrosine amino transferase (TAT) promoter and less complex promoters comprised of isolated glucocorticoid response element (GRE) sequences. AL 082D06 competes with3H-Dex for baculovirus-expressed GR with nanomolar affinity. Other intracellular receptors (AR, ER, PR, and MR) have no affinity for AL 082D06 in a similarly structured binding assay with the appropriate receptor and tritiated ligand (>2500 nM). AL 082D06 has no activation efficacy on the progesterone, androgen, mineralocorticoid, retinoid, glucocorticoid, or estrogen receptors. AL 082D06 is very efficacious at antagonizing GR activity but exhibits much weaker efficacy when tested against the other steroid receptors in contrast to the reference antagonists used as controls[1].

分子量

409.91

性状

Solid

Formula

C23H24ClN3O2

CAS 号

256925-03-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 7.5 mg/mL(18.30 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.4396 mL12.1978 mL24.3956 mL
5 mM0.4879 mL2.4396 mL4.8791 mL
10 mM0.2440 mL1.2198 mL2.4396 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。