CAS NO: | 2222344-98-9 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
生物活性 | ORIC-101 is a highly potent and selectiveglucocorticoid receptorantagonist, with anEC50of 5.6 nM. Anti-cancer activity. | ||||||||||||||||
IC50& Target | EC50: 5.6 nM (Glucocorticoid receptor)[1] | ||||||||||||||||
体外研究 (In Vitro) | ORIC-101 shows markedly reduced androgen receptor agonism (EC50, 2500 nM) and CYP2C8 and CYP2C9 inhibition profiles (IC50, >10 μM)[1]. | ||||||||||||||||
体内研究 (In Vivo) | ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) enhances the anti-tumor activity in combination with gemcitabine and carboplatin in OVCAR5 xenograft tumor in cortisol-treated mice[1].
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Clinical Trial | |||||||||||||||||
分子量 | 501.74 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C34H47NO2 | ||||||||||||||||
CAS 号 | 2222344-98-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 100 mg/mL(199.31 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |