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ORIC-101
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ORIC-101图片
CAS NO:2222344-98-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
ORIC-101 是一种有效、选择性的糖皮质激素受体 (glucocorticoid receptor) 拮抗剂,EC50值为 5.6 nM。抗癌作用。
生物活性

ORIC-101 is a highly potent and selectiveglucocorticoid receptorantagonist, with anEC50of 5.6 nM. Anti-cancer activity.

IC50& Target

EC50: 5.6 nM (Glucocorticoid receptor)[1]

体外研究
(In Vitro)

ORIC-101 shows markedly reduced androgen receptor agonism (EC50, 2500 nM) and CYP2C8 and CYP2C9 inhibition profiles (IC50, >10 μM)[1].
ORIC-101 (1-1000 nM) dose-dependently reduces the expression of n GR-mediated target gene (FKBP5 and GILZ), with IC50s of 17.2 and 21.2 nM, respectively[1].

体内研究
(In Vivo)

ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) enhances the anti-tumor activity in combination with gemcitabine and carboplatin in OVCAR5 xenograft tumor in cortisol-treated mice[1].

Animal Model:OVCAR5 xenograft tumor in cortisol-treated mice[1]
Dosage:75 mg/kg with 100 mg/kg gemcitabine and 60 mg/kg carboplatin
Administration:P.O. twice a day for 16-22 days
Result:Significantly reduced tumor volume in combination with chemotherapeutic agents.
Clinical Trial
分子量

501.74

性状

Solid

Formula

C34H47NO2

CAS 号

2222344-98-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL(199.31 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.9931 mL9.9653 mL19.9306 mL
5 mM0.3986 mL1.9931 mL3.9861 mL
10 mM0.1993 mL0.9965 mL1.9931 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。