CAS NO: | 1496508-34-9 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Dazucorilant (CORT113176) is a selective and high affinity non-steroidalglucocorticoid receptor(GR) modulator with aKivalue <1 nM in vitro. Dazucorilant can be used for the research of neurological disorders[1][2]. | ||||||||||||||||
IC50& Target | GR[1] | ||||||||||||||||
体外研究 (In Vitro) | In HepG2 human cells or in human hepatocytes, Dazucorilant acts as full antagonist since it is able to prevent the dexamethasone-induced increase in TAT activity and to induce non-measurable agonist activity in the absence of dexamethasone[3]. | ||||||||||||||||
体内研究 (In Vivo) | Dazucorilant (30 mg/kg/day; s.c.) makes mice show reversed abnormalities of motoneurons and down-regulated proinflammatory mediators and glial reactivity[1].
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Clinical Trial | |||||||||||||||||
分子量 | 582.57 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C29H22F4N4O3S | ||||||||||||||||
CAS 号 | 1496508-34-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |