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Hydrocortisone phosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hydrocortisone phosphate图片
CAS NO:3863-59-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Hydrocortisone 21-phosphate
Cortisol 21-phosphate
产品介绍
Hydrocortisone phosphate (Hydrocortisone 21-phosphate),一种糖皮质激素, 是口服活性的甾体抗炎剂 (SAID)。Hydrocortisone phosphate 抑制IL-6IL-3的生物活性,IC50值分别为 6.7 和 21.4 μM。Hydrocortisone phosphate 可用于溃疡性结肠炎 (UC) 的研究。
生物活性

Hydrocortisone phosphate (Hydrocortisone 21-phosphate), a physiological glucocorticoid, and is an orally active steroidal anti-inflammatory drug (SAID). Hydrocortisone phosphate inhibits proinflammatory cytokine activity, withIC50s of 6.7 and 21.4 μM forIL-6andIL-3, respectively. Hydrocortisone phosphate can be used for the research of ulcerative colitis (UC)[1][2][3].

IC50& Target[1]

IL-3

 

IL-6

 

IL-6

6.7 μM (IC50)

IL-3

21.4 μM (IC50)

体外研究
(In Vitro)

Hydrocortisone phosphate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3].
Hydrocortisone phosphate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3].

体内研究
(In Vivo)

Hydrocortisone phosphate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2].

Animal Model:Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2]
Dosage:30 mg/kg
Administration:P.o. twice daily for 5 days
Result:Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight.
Clinical Trial
分子量

442.44

Formula

C21H31O8P

CAS 号

3863-59-0

中文名称

磷酸氢化可的松

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.