CAS NO: | 1776112-90-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Mavelertinib is a selective, orally available and irreversibleEGFRtyrosine kinase inhibitor (EGFR TKI), withIC50s of 5, 4, 12 and 3 nM for Del, L858R, and double mutants T790M/L858R and T790M/Del, respectively. Mavelertinib can be used for the research of non-small-cell lungcancer(NSCLC)[1][2][3][4]. | ||||||||||||||||
IC50& Target | IC50: 3 nM (T790M/Del), 4 nM (L858R), 5 nM (Del), 12 nM (T790M/L858R), 307 nM (wild-type)[1] | ||||||||||||||||
体外研究 (In Vitro) | Mavelertinib exhibits selectivity over wild-type EGFR (IC50=307 nM)[1]. | ||||||||||||||||
体内研究 (In Vivo) | Mavelertinib exhibits low to moderate oral bioavailability (mouse 60%, rat 11%, dog 66%) following oral administration (mouse 1, rat 30, dog 3 mg/kg)[1].
| ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 415.42 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H22FN9O2 | ||||||||||||||||
CAS 号 | 1776112-90-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
| ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 47.5 mg/mL(114.34 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |