CAS NO: | 171179-06-9 |
包装 | 价格(元) |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | PD158780 is a potentEGFRfamily inhibitor withIC50s of 8 pM, 49, 52, 52 nM forEGFR, ErbB2, ErbB3, and ErbB4, respectively. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | PD158780 inhibits EGF receptor autophosphorylation in A431 human epidermoid carcinoma with IC50value of 13 nM. PD158780 is highly specific for the EGF receptor in Swiss 3T3 fibroblasts, inhibiting EGF-dependent receptor autophosphorylation and thymidine incorporation at low nanomolar concentrations while requiring micromolar levels for platelet-derived growth factor- and basic fibroblast growth factordependent processes. PD158780 inhibits heregulin-stimulated phosphorylation in the SK-BR-3 and MDAMB-453 breast carcinomas with IC50values of 49 and 52 nM, respectively, suggesting that the compound is active against other members of the EGF receptor family[1]. | ||||||||||||||||
体内研究 (In Vivo) | PD158780 is active against clone formation in several breast tumors having different expression patterns of the ErbB family. PD158780 shows good therapeutic effect against the A431 epidermoid carcinoma when administered either intraperitoneally or orally. PD158780 produces measurable, significant effects against a mouse fibroblast transfected with human EGFR. PD158780 produces a significant therapeutic effect against the estrogendependent MCF-7 breast carcinoma at equitoxic dose levels[1]. | ||||||||||||||||
分子量 | 330.18 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C14H12BrN5 | ||||||||||||||||
CAS 号 | 171179-06-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 16.67 mg/mL(50.49 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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