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Gefitinib-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gefitinib-d6图片
CAS NO:1228664-49-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
ZD1839-d6
产品介绍
Gefitinib-d6 (ZD1839-d6) 是 Gefitinib 的氘代物。Gefitinib (ZD1839) 是一种有效,选择性和口服活性的EGFR酪氨酸激酶抑制剂,IC50为 33 nM。Gefitinib 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50为 54 nM),并阻断 EGF 刺激的肿瘤细胞中EGFR自磷酸化。Gefitinib 还可诱导细胞自噬 (autophagy)。Gefitinib 具有抗肿瘤活性。
生物活性

Gefitinib-d6 (ZD1839-d6) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally activeEGFRtyrosine kinaseinhibitor with anIC50of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50of 54 nM) and that blocks EGF-stimulatedEGFRautophosphorylation in tumor cells. Gefitinib also inducesautophagy. Gefitinib has antitumour activity[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

452.94

Formula

C22H18D6ClFN4O3

CAS 号

1228664-49-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.