Gefitinib-d6 (ZD1839-d6) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally activeEGFRtyrosine kinaseinhibitor with anIC₅₀of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀of 54 nM) and that blocks EGF-stimulatedEGFRautophosphorylation in tumor cells. Gefitinib also inducesautophagy. Gefitinib has antitumour activity^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

452.94

C₂₂H₁₈D₆ClFN₄O₃

1228664-49-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.