CAS NO: | 2748162-29-8 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally activeEGFRinhibitor with anIC50of 15 nM forEGFRL858R/T790M[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | In Ba/F3 cells, JBJ-02-112-05 inhibits the activities of wildtype EGFR, EGFRL858R, EGFRL858R/T790Mand EGFRL858R/T790M/C797Swith IC50values of 9.29 μM; 8.35 μM; 8.53 μM and 2.13 μM, respectively[1]. | ||||||||
体内研究 (In Vivo) | JBJ-02-112-05 (100 mg/kg; oral gavage; once daily; for 3 days; EGFRL858R/T790M/C797Sgenetically engineered mice) treatment inhibits phosphorylation of EGFR and downstream signaling pathways[1].
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分子量 | 464.54 | ||||||||
Formula | C27H20N4O2S | ||||||||
CAS 号 | 2748162-29-8 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |