CAS NO: | 1879071-89-2 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | EGFR/HER2-IN-4(compound 6d) is an orally active irreversible dual inhibitor. EGFR/HER2-IN-4 inhibitsEGFRwith anIC50value of 0.6 nM and demonstrates potentEGFRkinase inhibitory activities on L858R and T790M mutations. EGFR/HER2-IN-4 has potent antitumor efficacy in vivo and can be used for lungcancerresearch[1]. | ||||||||||||||||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | EGFR/HER2-IN-4 (compound 6d) (0-10 μM, 72 hours) shows well anti-proliferative activity against human non-small cell lung cancer cell lines NCI-H1975 (T790M), HCC 827 (L858R) and human epithelial carcinoma cell lines A431[1]. Cell Proliferation Assay[1]
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体内研究 (In Vivo) | EGFR/HER2-IN-4 (compound 6d) (orally gavage; 5.1-81.4 mg/kg; for 25 days) has good cancer suppression effect in a dose-dependent manner in the constructed NCI-H1975 tumor xenograft model[1].
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分子量 | 487.95 | ||||||||||||||||||||||||||||||
Formula | C24H27ClFN5O3 | ||||||||||||||||||||||||||||||
CAS 号 | 1879071-89-2 | ||||||||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |