包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | PROTACEGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruitingPROTACEGFRL858R/T790Mdegrader, with aDC50of 13.2 nM.PROTACEGFR degrader 7 inhibits NCI–H1975 cells proliferation, with anIC50of 46.82 nM.PROTACEGFR degrader 7 significantly inducesapoptosisand G2/M phase arrest in NCI–H1975 cell.PROTACEGFR degrader 7 shows antitumor activity, and can be used for non-small cell lungcancer(NSCLC) research[1]. | |
IC50& Target |
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体内研究 (In Vivo) | PROTAC EGFR degrader 7 (compound 13b) (BALB/c mice bearing NCI–H1975 cells, 10 mg/kg, IP, once a day for 24 days) effectively and selectively inhibits NCI–H1975 xenograft tumor growth, with the tumor growth inhibition (TGI%) of 63.7%[1]. | |
分子量 | 836.94 | |
Formula | C46H48N10O6 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |