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EGFR-IN-46
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
EGFR-IN-46图片
CAS NO:2764772-88-3
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
EGFR-IN-46 是一种有效的EGFR和FAK双重抑制剂，IC50s 分别为 20.17 nM，14.25 nM。EGFR-IN-46 显著抑制癌细胞的生长。EGFR-IN-46 诱导细胞凋亡 (apoptosis)sup>[1]。
生物活性

EGFR-IN-46 is a potentEGFRandFAKdual inhibitor withIC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth ofcancercells. EGFR-IN-46 induces cellapoptosis[1].

IC50& Target[1]

EGFR

20.17 nM (IC50)

FAK

14.25 nM (IC50)

体外研究
(In Vitro)

EGFR-IN-46 (compound 6h) (0-100 μM; 24 h) inhibits the growth activity against DLD1, HCT-116 cells with IC50s of 1.79, 3.28 μM, respectively[1].
EGFR-IN-46 (3 μM; 24 h) induces cell apoptosis in DLD1 cells[1].
EGFR-IN-46 exhibits weak TOP1 (Topoisomerase I) poisoning effect (-/+)[1].

Cell Proliferation Assay[1]

Cell Line:DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells
Concentration:10 μM
Incubation Time:24 h
Result:Showed excellent growth inhibition with the percent growth inhibition of 92.36%, 89.34%, 84.76%, 90.36%, 90.78% for DLD1, HCT-116, MDMBA-231, MCF-7, Hela cells, respectively.

Apoptosis Analysis[1]

Cell Line:DLD1 cells
Concentration:3 μM
Incubation Time:24 h
Result:Increased the total percentage of apoptotic cells from 7% to 90.33%.
分子量

503.56

Formula

C27H32F3N3O3

CAS 号

2764772-88-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.