| CAS NO: | 1621866-96-3 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 生物活性 | AZD1208 hydrochloride is an orally bioavailable, highly selectivePIMkinases inhibitor[1]. | ||||||||||||||||
| IC50& Target | PIM[1] | ||||||||||||||||
| 体外研究 (In Vitro) | AZD1208 hydrochloride shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50values less than 100 nM[1]. AZD1208 hydrochloride (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cells at 1 μM. AZD1208 hydrochloride induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 hydrochloride and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3]. | ||||||||||||||||
| Clinical Trial | |||||||||||||||||
| 分子量 | 415.94 | ||||||||||||||||
| Formula | C21H22ClN3O2S | ||||||||||||||||
| CAS 号 | 1621866-96-3 | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. | ||||||||||||||||
| 溶解性数据 | In Vitro: DMSO : 83.3 mg/mL(200.27 mM;Need ultrasonic and warming) 配制储备液
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