Pimozide-d4-1 is the deuterium labeled Pimozide. Pimozide is adopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibitsSTAT3andSTAT5^[1][2][3][4].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[4].

465.57

Solid

C₂₈H₂₅D₄F₂N₃O

Room temperature in continental US; may vary elsewhere.