CAS NO: | 1888305-17-6 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | ERK5-IN-4 (compound 34b) is a potent and selective inhibitor ofextracellular signal-related kinase 5(ERK5). ERK5-IN-4 inhibitsERK5(full-length) and truncatedERK5(ERK5 ΔTAD) kinase activity in HEK293 cells with anIC50of 77 nM and 300 nM, respectively[1]. | ||||||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | ERK5-IN-4 (compound 34b) is selective against MAP3K, p38 (IC50>30 μM) and BRD4 (IC50>20 μM), in contrast to many reported ERK5 inhibitors[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | ERK5-IN-4 (compound 34b) (p.o.; 10 mg/kg) has low clearance and an oral bioavailability of 42% in the mouse[1].
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分子量 | 381.19 | ||||||||||||||||||||
Formula | C16H11Cl2FN4O2 | ||||||||||||||||||||
CAS 号 | 1888305-17-6 | ||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |