Lidocaine (Lignocaine) hydrochloride hydrate inhibitssodium channelsinvolving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation ofMEK/ERKandNF-κBsignaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia^[1][2].

Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation^[2].
Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10 nM and treatment time 48 hours^[2].
Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate^[2].
Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly^[2].

Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block^[3].

288.81

C₁₄H₂₅ClN₂O₂

6108-05-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.