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Anti-inflammatory agent 31
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Anti-inflammatory agent 31图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Anti-inflammatory agent 31 是一种穿心莲内酯衍生物,是一种抗炎剂 (anti-inflammatoryagent)。Anti-inflammatory agent 31 通过上游阻断PI3K/AktERK1/2 MAPK激活来抑制NF-kB激活。Anti-inflammatory agent 31 能够恢复细胞内 GSH 水平并对肝脏具有保护作用。
生物活性

Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is aanti-inflammatoryagent. Anti-inflammatory agent 31 inhibitsNF-κBactivation by upstream blockade ofPI3K/AktandERK1/2 MAPKactivation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver[1].

IC50& Target

ERK1

 

ERK2

 

体外研究
(In Vitro)

Anti-inflammatory agent 31 (enone 17) (100, 200, and 400 μM; 24 h) prevents the DNA binding of the activated NF-κB p50 subunit in a dose-dependent manner[1].
Anti-inflammatory agent 31 reacts as a quick rate (KGSH=0.076 M-1.h-1) and long half-live (T1/2=6.47 h)[1].
Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) shows recovery effective of the intracellular GSH levels, and (5 μM) induced more than 2.5-fold increase in GSH levels as compared to the basal levels[1].
Anti-inflammatory agent 31 (5, 20, and 50 μM; 24 h) displays low cytotoxicity in LO2 and HEK293 cells with CC50of 14.68, 26.25 μM, respectively[1].

Immunofluorescence[1]

Cell Line:RAW-blueTMcells
Concentration:5, 10, 20 μM
Incubation Time:24 hours
Result:Inhibited the LPS-induced NF-κB activity and indicated the anti-inflammatory properties.
体内研究
(In Vivo)

Anti-inflammatory agent 31 (enone 17) (i.p.; 0.3, 1.0 mg/kg) decreases total white blood cell and neutrophils counts, and alleviates LPS-induced acute lung injury in a dose-dependent manner in mouse[1].

Animal Model:LPS-induced acute lung injury (ALI) mouse model (female BALB/c mice; 7-week-old)[1]
Dosage:0.3, 1.0 mg/kg
Administration:Intraperitoneal injection 1 h after LPS challenge; twice daily for 4 days
Result:Alleviated LPS-induced acute lung injury.
分子量

306.44

Formula

C19H30O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.