HIOC

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HIOC

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

314054-36-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

HIOC 是一种强效选择性的TrkB(原肌球蛋白相关激酶b) 受体的激活剂。HIOC 可以通过血脑和血视网膜屏障。HIOC 激活TrkB/ERK通路，减少神经元细胞死亡。HIOC 减轻蛛网膜下出血 (SAH) 后早期脑损伤。HIOC 在光致视网膜变性的动物模型中显示出保护作用。

生物活性

HIOC is a potent and selective activator ofTrkB(tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activatesTrkB/ERKpathway and decreases neuronal cellapoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). HIOC shows protective activity in an animal model for light-induced retinal degeneration^[1]^[2]^[3].

IC₅₀& Target

TrkB

ERK

体内研究
(In Vivo)

HIOC (C57BL/6 mice, 50 mg/kg, IP, three times per week, for two weeks) increased survival of RGCs (retinal ganglion cells) after ONC (optic nerve crush)^[3].

分子量

301.34

Formula

C₁₆H₁₉N₃O₃

CAS 号

314054-36-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.