SS47

立即咨询

SS47

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2636072-62-1

包装与价格：

产品介绍

SS47 是一种基于PROTAC的HPK1降解剂，可发挥蛋白酶体介导的 HPK1 降解。SS47 降解 HPK1 也显着增强了 BCMA CAR-T 细胞治疗的体内抗肿瘤功效。HPK1 是一种免疫抑制调节激酶，是肿瘤免疫疗法的有潜力靶点。

生物活性	SS47, aPROTAC-basedHPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the in vivo antitumor efficacy of BCMA CAR-T cell treatment. HPK1, an immunosuppressive regulatory kinase, is a promising target forcancerimmunotherapies^[1].
分子量	953.07
Formula	C₄₉H₅₆N₆O₁₂S
CAS 号	2636072-62-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.