CAS NO: | 2672512-44-4 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | MS432 is a first-in-class and highly selective PD0325901-basedvon Hippel-Lindau-recruitingPROTACdegrader forMEK1andMEK2. MS432 displays good plasma exposure in mice, exhibitingDC50values of 31 nM and 17 nM forMEK1,MEK2in HT29 cells respectively[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | MS432 (compound 23) is potent in reducing MEK1/2 protein levels in COLO 205 cells (DC50(MEK1) = 18 ± 7 nM, DC50(MEK2) = 11 ± 2 nM) and UACC257 cells (DC50(MEK1) = 56 ± 25 nM, DC50(MEK2) = 27 ± 19 nM). Cell Viability Assay[1]
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体内研究 (In Vivo) | MS432 (compound 23) displays good plasma exposure, which is approximately 3 to 20-fold higher than the GI50values of compound 23 in the tested cancer cell lines[1].
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分子量 | 1076.06 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C50H65F3IN7O6S | ||||||||||||||||
CAS 号 | 2672512-44-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 260 mg/mL(241.62 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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