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Vemurafenib-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vemurafenib-d5图片
CAS NO:1365986-90-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议

产品名称
维罗非尼 d5
产品介绍
Vemurafenib-d5 (PLX4032-d5) 是 Vemurafenib 的氘代物。Vemurafenib (PLX4032; RG7204; RO5185426) 是首创的,有效的B-RAF选择性抑制剂,能够抑制 RAFV600E和 c-RAF-1 的活性,IC50分别为 31 nM 和 48 nM。Vemurafenib 可以诱导细胞自噬 (autophagy)。
生物活性

Vemurafenib-d5 (PLX4032-d5) is the deuterium labeled Vemurafenib. Vemurafenib (PLX4032) is a first-in-class, selective, potent inhibitor ofB-RAFkinase, withIC50s of 31 and 48 nM forRAFV600Eand c-RAF-1, respectively[1][4]. Vemurafenib induces cellautophagy[5].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

494.95

Formula

C23H13D5ClF2N3O3S

CAS 号

1365986-90-8

中文名称

维罗非尼 d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.