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25-Hydroxycholesterol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
25-Hydroxycholesterol图片
CAS NO:2140-46-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
25-Hydroxycholesterol是胆固醇的代谢产物,由巨噬细胞响应Toll样受体(TLR)激活而产生和分泌。25-Hydroxycholesterol有效且选择性抑制B细胞产生IgA,EC50约为65nM。
Cas No.2140-46-7
别名25-羟基胆固醇
化学名cholest-5-ene-3β,25-diol
Canonical SMILESCC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
分子式C27H46O2
分子量402.65
溶解度20mg/mL in ethanol, 2mg/mL in DMF, 100μg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1].

[1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.