CAS NO: | 862974-25-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | N106 is a first-in-classsarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylationactivator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research[1]. | ||||||||||||||||
体外研究 (In Vitro) | N106 treatment increases contractile properties of cultured rat cardiomyocytes. N106 increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation within 10 min of exposure, and these effects are sustained at 24 h in cardiomyocytes[1]. | ||||||||||||||||
体内研究 (In Vivo) | In a murine model, the half-life of N106 is determined to be ~65.4 min with a Cmaxof ~2.24 μM when the mice received 10 mg/kg of N106 by intravenous injection. The oral bioavailability (F%) is 56% and 50%, and terminal elimination half-life (t1/2) is 19 min[1]. | ||||||||||||||||
分子量 | 354.38 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H14N4O3S | ||||||||||||||||
CAS 号 | 862974-25-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 62.5 mg/mL(176.36 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |