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N106
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N106图片
CAS NO:862974-25-2
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
N106 是首创的肌质网钙 ATP 酶 (SERCA2a) SUMOylation 激活剂。N106 直接激活 SUMO 激活酶 E1 连接酶。N106 可用于心力衰竭研究。
生物活性

N106 is a first-in-classsarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylationactivator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research[1].

体外研究
(In Vitro)

N106 treatment increases contractile properties of cultured rat cardiomyocytes. N106 increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation within 10 min of exposure, and these effects are sustained at 24 h in cardiomyocytes[1].

体内研究
(In Vivo)

In a murine model, the half-life of N106 is determined to be ~65.4 min with a Cmaxof ~2.24 μM when the mice received 10 mg/kg of N106 by intravenous injection. The oral bioavailability (F%) is 56% and 50%, and terminal elimination half-life (t1/2) is 19 min[1].
In vivo, N106 (10 mg/kg) increases cardiac SERCA2A SUMOylation, and significantly improves ventricular function in mice with heart failure[1].

分子量

354.38

性状

Solid

Formula

C17H14N4O3S

CAS 号

862974-25-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 62.5 mg/mL(176.36 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.8218 mL14.1091 mL28.2183 mL
5 mM0.5644 mL2.8218 mL5.6437 mL
10 mM0.2822 mL1.4109 mL2.8218 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。