您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Cyclic ADP-ribose ammonium
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Cyclic ADP-ribose ammonium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cyclic ADP-ribose ammonium图片
包装:500 μg
市场价:7200元

产品名称
cADPR ammonium
产品介绍
Cyclic ADP-ribose ammonium (cADPR ammonium) 是一种有效的钙动员 (calcium mobilization) 第二信使,是通过 ADP-核糖基环化酶从 NAD+合成的。Cyclic ADP-ribose ammonium 主要通过Ryanodine受体介导的内质网释放以及通过TRPM2通道开放引起的细胞外流入来增加胞质钙。
生物活性

Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger forcalcium mobilizationthat is synthesized from NAD+by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly byRyanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening ofTRPM2 channels[1][2][3].

IC50& Target

Calcium mobilization[1]
TRPM2 channels[3]
Endogenous metabolite[1]

体外研究
(In Vitro)

cADPR (20 nM) elicits a large rapid Ca2+release in sea urchin eggs homogenates[1].
cADPR (100 μM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes[4].
cADPR (100 μM) and heat (35-38.5 ℃) stimulates oxytocin OT release from the isolated hypothalami of male mice in culture[5].

体内研究
(In Vivo)

cADPR (100 μM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice[5].

性状

Solid

Formula

C15H21N5O13P2.xNH3

结构分类
  • Others
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)