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Aminophylline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aminophylline图片
CAS NO:317-34-0
规格:≥98%
包装与价格:
包装价格(元)
1g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)420.43
FormulaC16H24N10O4
CAS No.317-34-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 53 mg/mL (126.1 mM)
Water: 84 mg/mL (199.8 mM)
Ethanol: <1 mg/L
Chemical Name1,3-Dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine
SynonymsCardophyllin; Aminophyllin; Aminophylline; Theophyllamine; Phyllocontin; Euphyllin; Truphylline; Minomal R 175 mg tab; Minomal R 350 mg tab; Minomal SR 600 mg tab

Chemical Name: 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione compound with ethane-1,2-diamine (2:1)

InChi Key: FQPFAHBPWDRTLU-UHFFFAOYSA-N

InChi Code: InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2

SMILES Code: CN1C2=C(NC=N2)C(N(C)C1=O)=O.CN3C4=C(NC=N4)C(N(C)C3=O)=O.NCCN

实验参考方法
In Vitro

In vitro activity: Aminophylline causes bronchodilation, diuresis, central nervous system and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis, and induces release of epinephrine from adrenal medulla cells.


Kinase Assay: Aminophylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene[14] synthesis, and reduces inflammation and innate immunity and nonselective adenosine receptor antagonist.

References Acad Emerg Med. 2003 Mar;10(3):192-7.