CAS NO: | 1413431-07-8 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
生物活性 | Ivacaftor-D9 (CTP-656) is a potentCFTR modulatorand exhibits anEC50value of 255 nM forCFTRpotentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1]. |
体内研究 (In Vivo) | In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters Cmax, AUC0-24 hr, C24hrand t1/2of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters Cmax, AUC0-24 hr, C24hrand t1/2of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg). |
Clinical Trial | |
分子量 | 401.55 |
Formula | C24H19D9N2O3 |
CAS 号 | 1413431-07-8 |
中文名称 | 依伐卡托 D9 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |