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Ivacaftor-D9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ivacaftor-D9图片
CAS NO:1413431-07-8
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
VX-770-d9
产品介绍
Ivacaftor-D9 (CTP-656) 是一种有效的CFTR调节剂,在 G551D/F508del HBE 细胞中 CFTR 增强的EC50值为 255 nM。Ivacaftor- d9 作为一种具有口服活性和改良的 Ivacaftor 氘化物用于囊性纤维化研究。
生物活性

Ivacaftor-D9 (CTP-656) is a potentCFTR modulatorand exhibits anEC50value of 255 nM forCFTRpotentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

体内研究
(In Vivo)

In PK study, CTP-656 (oral gavage; 10 mg/kg; single dose) shows a superior pharmacokinetic profile, The plasma levels of compound were measured over 72 hours,exhibits the parameters Cmax, AUC0-24 hr, C24hrand t1/2of 1970 ng/ml (15%), 24,260 hr*ng/ml(17%), 413 ng/ml (19%) and 13.9 hours, respectively in Male Sprague-Dawley rats.
CTP-656 (oral gavage; 3 mg/kg; single dose) exhibits the parameters Cmax, AUC0-24 hr, C24hrand t1/2of 3643 ng/ml (9%), 49,782 hr*ng/ml(31%), 1418 ng/ml (31%) and 22.8 hours, respectively in Male Beagle Dogs (3.0 mg/kg).

Clinical Trial
分子量

401.55

Formula

C24H19D9N2O3

CAS 号

1413431-07-8

中文名称

依伐卡托 D9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.