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CFTR corrector 4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CFTR corrector 4图片
CAS NO:1918142-34-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
CFTR corrector 4,化合物 13,是一种有效的 (R,R) 型活性对映体,是一种高效且口服的囊性纤维化跨膜电导调节剂 (CFTR) 校正剂。CFTR corrector 4 可以增加细胞表面的 CFTR 水平,有潜力用于囊性纤维化的研究。
生物活性

CFTRcorrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally activecystic fibrosis transmembrane conductance regulator (CFTR)corrector.CFTRcorrector 4 can increaseCFTRlevels at the cell surface and have the potential for treatment of cystic fibrosis[1].

IC50& Target

EC50:130 nM (CFTR)[1]

体外研究
(In Vitro)

CFTR corrector 4 possesses high potency and efficacy with a EC50of 0.028 μM in this HBE-TECC assay that assess the CFTR function, this lead resides in undesirable drug-like space with high molecular weight, and high HPLC Log D, indicating high lipophilicity. HBE-TECC: (Human Bronchial Epithelial-Trans-Epithelial Current Clamp) assay[1].
CFTR corrector 4 is tested its potency and efficacy in human bronchial epithelial (HBE) cells with a EC50value 130 nM in the cell surface expression (CSE-HRP) assay[1].

分子量

539.52

性状

Solid

Formula

C29H27F2NO7

CAS 号

1918142-34-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month