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Posenacaftor
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Posenacaftor图片
CAS NO:2095064-05-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
PTI-801
产品介绍
Posenacaftor (PTI-801) 是一种囊性纤维化跨膜调节蛋白 (CFTR) 调节剂,可纠正 CFTR 蛋白的折叠和运输。Posenacaftor 用于囊性纤维化 (CF) 的研究。
生物活性

Posenacaftor (PTI-801) is acystic fibrosis transmembrane regulator (CFTR) proteinmodulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF)[1].

体外研究
(In Vitro)

Cystic fibrosis (CF) is an autosomal recessive disorder, caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR)[1].
CFTR is a cAMP-regulated chloride channel that is primarily located at the apical membrane of epithelial cells. Mutations in the CFTR gene lead to the production of a defective and misfolded CFTR protein, and impairs the flow of ions in and out of cells[1].
Posenacaftor is a CFTR corrector, correctors are designed to fix and restore the function of the defective CFTR protein. The corrected CFTR then moves to the cell surface, where it functions as a chloride channel and helps maintain the right balance of fluid in the airways[2].

Clinical Trial
分子量

445.51

Formula

C27H27NO5

CAS 号

2095064-05-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.