CAS NO: | 130477-52-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | L-655708 is a potent α5 subunit-selectiveGABAAreceptor inverse agonist (Ki=0.45 nM). | ||||||||||||||||
体外研究 (In Vitro) | L655708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 orα6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity. | ||||||||||||||||
体内研究 (In Vivo) | L-655708 at 0.7 mg/kg, administered intraperitoneally, would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1, α2, and α3 subunit-containing GABAA receptors and no significant off-target behavioral effects, such as sedation and motor impairment. | ||||||||||||||||
分子量 | 341.36 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H19N3O4 | ||||||||||||||||
CAS 号 | 130477-52-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 20 mg/mL(58.59 mM;Need ultrasonic) 配制储备液
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