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Acamprosate calcium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Acamprosate calcium图片
CAS NO:77337-73-6
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
50mg电议
100mg电议
200mg电议

产品名称
Calcium N-acetylhomotaurinate
产品介绍
Acamprosate calcium(Campral EC)是GABA受体激动剂和谷氨酸能系统调节剂。
生物活性

Acamprosate calcium(Campral EC) is aGABA receptor agonistand modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. IC50 value: Target:GABA receptorAcamprosate, or N-acetyl homotaurine, is an N-methyl-D-aspartate receptor modulator approved by the Food and Drug Administration (FDA) as a pharmacological treatment for alcohol dependence.Acamprosate has low bioavailability, but also has an excellent tolerability and safety profile. In comparison with naltrexone and disulfiram, which are the other FDA-approved treatments for alcohol dependence, acamprosate is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so can be administered to patients with hepatitis or liver disease (a common comorbid condition among individuals with alcohol dependence) and to patients who continue drinking alcohol.

Clinical Trial
分子量

200.24

性状

Solid

Formula

C5H10NO4S.1/2Ca

CAS 号

77337-73-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(499.40 mM;Need ultrasonic)

DMSO :< 1 mg/mL(insoluble or slightly soluble)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM4.9940 mL24.9700 mL49.9401 mL
5 mM0.9988 mL4.9940 mL9.9880 mL
10 mM0.4994 mL2.4970 mL4.9940 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。