您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > ML 348
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
ML 348
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ML 348图片
CAS NO:899713-86-1
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议

产品介绍
ML 348 (GNF-Pf-1127) 是一种选择性和可逆的酰基蛋白硫酯酶 1 (APT1)/溶血磷脂酶 1 (LYPLA1) 抑制剂，IC50 为 210 nM，几乎不抑制 LYPLA2。
Cas No.899713-86-1
别名GNF-Pf-1127
化学名N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamide
Canonical SMILESClC1=C(NC(CN2CCN(C(C3=CC=CO3)=O)CC2)=O)C=C(C(F)(F)F)C=C1
分子式C18H17ClF3N3O3
分子量415.79
溶解度≥ 19.1mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1].

ML348 (5 μM; 3 hours ) selectively inhibits LYPLA1 in cultured cells[1].

ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice[1].

References:
[1]. Adibekian A et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1). National Center for Biotechnology Information (US); 2010- 2013 Apr 08.