D-Serine

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D-Serine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

312-84-5

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
500mg	电议
1 g	电议
5 g	电议
10 g	电议
50 g	电议

产品名称

D-丝氨酸
(R)-Serine

产品介绍

D-Serine ((R)-Serine) 是一种具有独特的神经递质特性的神经胶质-突触相互作用中涉及的内源性氨基酸，是NMDA谷氨酸受体的有效共激动剂。D-Serine 在主要的 NMDAR 依赖性过程中具有主要的调节作用，包括 NMDAR 介导的神经传递，神经毒性，突触可塑性和细胞迁移。

生物活性

D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at theNMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration^[1]^[2].

IC₅₀& Target

NMDA Receptor

Human Endogenous Metabolite

体外研究
(In Vitro)

(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR^[3].

体内研究
(In Vivo)

(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain^[4].

Animal Model:	Four week old male C57Bl/6 mice
Dosage:	10 g/L
Administration:	Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeks
Result:	Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.

Clinical Trial

分子量

105.09

性状

Solid

Formula

C₃H₇NO₃

CAS 号

312-84-5

结构分类

Amino acids

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : ≥ 50 mg/mL(475.78 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	9.5157 mL	47.5783 mL	95.1565 mL
5 mM	1.9031 mL	9.5157 mL	19.0313 mL
10 mM	0.9516 mL	4.7578 mL	9.5157 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 50 mg/mL (475.78 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。