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Transcrocetin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Transcrocetin图片
CAS NO:27876-94-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
藏红花酸
trans-Crocetin
产品介绍
Transcrocetin 从藏红花 (Crocus sativus L.) 中提取的,是一种可透过血脑屏障的,高亲和力的NMDA受体拮抗剂。
生物活性

Transcrocetin (trans-Crocetin), extracted from saffron (Crocus sativus L.), acts as anNMDA receptorantagonist with high affinity[1]. Transcrocetin (trans-Crocetin) is capable of crossing the blood-brain barrier and reach the central nervous system (CNS)[2].

IC50& Target

NMDA Receptor

 

体外研究
(In Vitro)

Transcrocetin (trans-Crocetin), a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 μM) reveal no negative significant changes in cellular viability. Transcrocetin at 10 μM level does not change viability while higher concentrations (40-160 μM) reduces significantly cellular viability[1].

Clinical Trial
分子量

328.40

性状

Solid

Formula

C20H24O4

CAS 号

27876-94-4

中文名称

藏红花酸;西红花酸;番红花酸

结构分类
  • Terpenoids
  • Diterpenoids
来源
  • Plants
  • Lridaceae
  • Crocus sativusL.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

溶解性数据
In Vitro: 

DMSO : 1 mg/mL(3.05 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.0451 mL15.2253 mL30.4507 mL
5 mM---------
10 mM---------
*

请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用